LCN2 and viral infectious disease: Although a subset of positively correlated genes with viral infection severity (CAMP, BCAT1, LCN2, TXN) have known proinflammatory functions in myeloid cells (Bertini et al., 1999; Bruns et al., 2015; Choi and Fujii, 2019; Eriksson et al., 2017; Papathanassiu et al., 2017; Ramos-Martínez et al., 2018) (Figure S4C), we found strong evidence of increased myeloid cell-derived immune suppression in patients with severe viral infection.