Expression of HLA-DPB1 was lower in several antigen presenting cells (CD14 monocytes, conventional dendritic cells (cDCs), and B cells) in patients with moderate and severe viral infection in three scRNA-seq cohorts (Figures S5C and S5D) along with a reduced proportion of cDCs in severe viral infections in both scRNA-seq (Figure S5E) and bulk transcriptome deconvolution (Table S4). The gene discussed is HLA-DPB1; the disease is viral infectious disease.