As observed in Nrf2-/- mice, dKO mice presented greater ROS levels at week 6 post-infection (Fig 2E) and less expression of NRF2-target genes Hmox1 and Nqo1 as measured at week 3 post-infection on total footpad lesions caused by LgyLRV1+ parasites (S2E and S2F Fig). The gene discussed is HMOX1; the disease is infection.