Preoperatively, the 27-gauge group and 25-gauge group did not differ significantly in age, gender, glaucoma history, grading of TRD severity, best-corrected visual acuity (BCVA) in LogMAR, HbA1c, duration of DM, pre-operative PRP, or IVI of ant-VEGF (bevacizumab/ranibizumab/none). Here, VEGFA is linked to diabetes mellitus.