Among BCLC stage C patients, the mean age was highest, the proportions of male patients and those with tumor size >5.0 cm were lowest, the proportion of patients with AFP<20 ng/ml was highest, the proportion of HCCs diagnosed by pathology and with TNM stage 1 was highest, the bilirubin and INR levels were lowest, and the follow-up period was longer in the upward treatment stage migration group than in the other patient groups. This evidence concerns the gene AFP and neoplasm.