AFP and hepatocellular carcinoma: Among BCLC stage D patients, upward treatment stage migration (HR = 0.144, 95%CI = 0.043–0.483, p = 0.002), BMI per 1 unit increase (HR = 1.077, 95%CI = 1.003–1.157, p = 0.004), AFP level > vs. ≦200 ng/ml (HR = 2.246, 95%CI = 1.233–4.093, p = 0.008), HCC diagnosed by pathology vs. clinical (HR = 0.466, 95%CI = 0.239–0.909, p = 0.025), and TNM stage 4 vs. 1 (HR = 4.874, 95%CI = 1.462–15.651, p = 0.01) were independent predictors for OS (Table 12).