AFP and Cirrhosis: Among BCLC stage A patients, downward treatment stage migration (HR = 1.881, 95%CI = 1.342–2.638, p<0.001), age > 65 years (HR = 1.369, 95%CI = 1.041–1.801, p = 0.025), cirrhosis status (HR = 1.539, 95%CI = 1.081–2.193, p = 0.017), and AFP level > vs. ≦200 ng/ml (HR = 1.804, 95%CI = 1.321–2.464, p<0.001) were independent predictors for OS (Table 9).