In line with such reports and our finding of a substantial overexpression of PALLD in the tumor stroma (CAFs) in compartment-specific gene expression data from human precursor lesions and PDAC specimen, and in the tissue of the affected patient, we propose here that a palladin germline mutation, just like the one in Family X, could convey a stromal predisposition to developing pancreatic cancer. This evidence concerns the gene PALLD and neoplasm.