Besides, it is important to note that the ligand affinity of Olfr78 for SCFAs is lower than the one presented in FFAR3.109 Taken together, the SCFA receptors Olfr78 and FFAR3 might play an opposing role in the regulation of blood pressure, balancing each other to have a healthy blood pressure.97 Moreover, using a Mendelian Randomization approach, Sun and coworkers110 reported T2D may causally affect hypertension and particularly higher systolic blood pressure. This evidence concerns the gene FFAR3 and hypertensive disorder.