Silibinin, a potent natural agent derived from dried fruits of milk thistle (Silybum marianum),33 suppressed mesenchymal gene expression including ZEB1 and reversed suppression of miR‐200c signature in erlotinib‐refractory tumors; and, complete abrogation of tumor growth was observed after cotreatment with erlotinib and silibinin. The gene discussed is ZEB1; the disease is neoplasm.