CC-885 and CC-90009 have recently been identified as ‘molecular glue’ compounds that co-opt the CUL4-DDB1-CRBN-RBX1 (CRL4CRBN) E3 ubiquitin ligase complex to trigger the ubiquitination and proteasomal degradation of eRF3a in AML cell lines (22,24). This evidence concerns the gene RBX1 and acute myeloid leukemia.