MAP2K7 and cancer: In the human, sorafenib dosed at 10 mg/kg BW/day (Yang and Liu 2017) noticeably targets the RAF/MEK (Mitogen activated protein/ERK kinase)/ERK (Extracellular Receptor Kinase) signaling pathway, which is considered to be important in cancer as it regulates key cellular processes relevant to the so-called cancer hallmarks, most notably, increased cell growth and survival (Chang et al. 2003).