TP53 and glioblastoma: Furthermore, 27 did not affectthe viability of a GBM cell line expressing mutant p53, while it wasable to impair the proliferation of glioma cancer stem cells (CSCs),that are resistant to therapies and responsible for GBM recurrence.In addition, compound 27 was shown to preferentiallydirect its antiproliferative effect toward tumor cells compared tohealthy ones.82