BRCA1 and breast carcinoma: The higher odds ratio for BRCA1 in our study is therefore likely to be explained by the strong family history of breast and/or ovarian cancer in relatives rather than a true association with BRCA1. Although the MS is specifically used for BRCA1/2, it does contain an element of assessing high risk for inherited breast cancer by scoring all breast cancers in the lineage and increasing the score in younger cases.