The higher odds ratio for BRCA1 in our study is therefore likely to be explained by the strong family history of breast and/or ovarian cancer in relatives rather than a true association with BRCA1. Although the MS is specifically used for BRCA1/2, it does contain an element of assessing high risk for inherited breast cancer by scoring all breast cancers in the lineage and increasing the score in younger cases. Here, BRCA1 is linked to ovarian cancer.