Additionally, our results indicate that Tyr705 phosphorylation of STAT3 plays an important role in this induction of CD54 on tumor-infiltrating neutrophils by GM-CSF in the GC environment and provides evidence that tumor-infiltrating neutrophils increase expression of both CD54 and B7-H4, which appear to be in both GM-CSF-dose-dependent and time-dependent manners. The gene discussed is CSF2; the disease is neoplasm.