MMP-9 has the largest molecular weight among the MMPs, and it can degrade almost all the extracellular matrix components, causing weakening of the adhesion between tumor cells and damaging barriers that prevent cancer cell invasion and metastasis, thus providing sufficient space for cancer cells to spread and metastasize to distant regions and promoting tumor growth, infiltration, and metastasis [18]. Here, MMP9 is linked to neoplasm.