The association between tslp overexpression and AD onset has already been established in vivo, as well as its modulation through botanicals or probiotic supplementation (61, 62), Here, we demonstrated for the first time that the gene expression is ruled by epigenetic mechanisms; in fact, we observed an increase of the DNA methylation as a consequence of the nutraceutical mixture treatment. The gene discussed is TSLP; the disease is Alzheimer disease.