ICAM1 and acute chest syndrome: Neutrophil-platelet-RBC aggregates have been demonstrated to be involved in ACS – a form of acute lung injury in the event of VOC in the lung vasculature (Bennewitz et al., 2017), and Sundd lab utilized a unique microfluidic device functionalized with immobilized p-selectin, intercellular adhesion molecule 1 (ICAM-1) and interleukin 8 (IL-8) (Bennewitz et al., 2014, 2017; Jimenez et al., 2017; Vats et al., 2019) to delineate aspects of neutrophil-platelet interactions in forming such aggregates.