Different from sperm or chemical-induced oocyte activation where high MAPK activity still lasts several hours after the stimulation (Fan and Sun, 2004), rat OSA exhibits a quick decrease in both Mos and MAPK kinase (MEK)/MAPK (Ito et al., 2007; Table 1), which could explain the reason underlying the disintegrated microtubules and failure of 2nd PB extrusion during OSA in some rat strains (Cui et al., 2012; Prasad et al., 2015). Here, MAP2K7 is linked to obstructive sleep apnea syndrome.