In addition, BTG4 was also identified as essential for MII arrest (Figure 1F), because excess polyadenylated mRNA caused by Btg4 knockdown could occupy the translational machinery, which then leads to an insufficient capacity of the oocyte to translate the mRNAs that are essential for MII arrest (e.g., mRNAs encoding EMI2), and all of this finally resulted in OSA to M-III (Pasternak et al., 2016). This evidence concerns the gene BTG4 and obstructive sleep apnea syndrome.