CAMK2G and obstructive sleep apnea syndrome: To block increase of (Ca2+)i and its cascade during OSA, Ca2+-free medium (Hayes et al., 2001; Sun et al., 2002; Premkumar and Chaube, 2013), Ca2+ chelator (Ito et al., 2007), multiple Ca2+ channel blockers (Chaube et al., 2007; Yoo and Smith, 2007), and CaMKII inhibitors (Ito et al., 2006; Yoo and Smith, 2007) have been applied (Table 1), but these methods cannot fully block OSA or can cause obvious side effects [reviewed in Chebotareva et al. (2011)].