However, the highest number of studies present in literature is related to P2X7’s role in AML of infancy and adulthood and to myelodysplastic syndromes (MDSs) (Zhang et al., 2004; Chong et al., 2010; Salvestrini et al., 2012, 2017; Lecciso et al., 2017; Feng et al., 2020; He et al., 2020; Pegoraro et al., 2020). Here, P2RX7 is linked to acute myeloid leukemia.