Consistently, administration of different P2X7 antagonists caused a significant reduction in AML growth and dissemination (De Marchi et al., 2019; He et al., 2020; Pegoraro et al., 2020), as well as an increase in overall survival (He et al., 2020) in various murine models of the disease, obtained both in xenotransplanted and syngeneic mice, thus confirming the efficacy of P2X7 blockade both on human leukemic cells and in hosts with a functional immune system. The gene discussed is P2RX7; the disease is acute myeloid leukemia.