These discording data, which could be due to limited knowledge at that time of other polymorphisms of the receptor or the presence of P2X7 splice variants, caused a long stop in the research trying to relate the receptor and B-CLL until a recent study that investigated the involvement of P2X7/NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome axis in this hematological condition (Salaro et al., 2016). This evidence concerns the gene NLRP3 and B-cell chronic lymphocytic leukemia.