P2RX7 and acute myeloid leukemia: The assumption that two different P2X7 splice variants could play contrasting roles in the presence of high ATP concentration can also help to reconcile the antitumoral effect played by both P2X7 antagonists and agonists (Salvestrini et al., 2017; De Marchi et al., 2019; Pegoraro et al., 2020) in reducing AML growth in murine models.