P2RX7 and plasma cell myeloma: Agrawal et al. (2020) recently suggested that P2X7 activated by high ATP concentrations can impair myeloma growth, inducing cell cycle arrest instead of apoptosis. Additionally, the authors hypothesized that P2X7 would affect the interaction among myeloma cells, osteoblasts, and osteoclasts, favoring mineralization and reversing osteoclastic resorption lines (Agrawal et al., 2020).