Although differential effects could also be due to different levels of the leptin receptor, it has previously been reported that both cell lines used in this investigation have similar levels of OBRb (Yom et al., 2013) and similar concentrations of leptin used have been shown to have effects on migration and metalloprotease secretion in the same breast cancer cell lines (Juarez-Cruz et al., 2019). Here, LEP is linked to breast cancer.