Jian et al. (2020) have reported the mechanism of METTL14-promoted endothelial inflammation and atherosclerosis through driving FOXO1 m6A modifications. They proved the major role of METTL14 in TNF-α-induced endothelial cell inflammation. As a process tightly associated with inflammation, cell senescence includes irreversible cell cycle arrest (Stojanovic et al., 2020). The gene discussed is FOXO1; the disease is inflammation.