PRKD1, a direct target of miR-34a, was capable of regulating cancer stemness in chemoresistant human breast cancer cells by altering GSK3/β-catenin signaling, and ectopic miR-34a expression reduced PRKD1 resulting in suppressed self-renewal of BCSCs (Kim Do et al., 2016). This evidence concerns the gene PRKD1 and breast carcinoma.