Interestingly, in glioma cells, miR-34a may downregulate the expression and promoter activity of EGFR through YY1 leading to growth inhibition (Yin et al., 2013), which suggests a novel mode of mechanism by which EGFR is modulated by the p53–miR-34a–YY1 pathway. The gene discussed is TP53; the disease is glioma.