TP53 and head and neck squamous cell carcinoma: A recent study by Amit et al. revealed an intriguing molecular mechanism of cancer-nerve crosstalk in head and neck squamous cell carcinoma (HNSCC), in which loss of TP53 leads to adrenergic transdifferentiation of tumor-associated sensory nerves through loss of miR-34a (Amit et al., 2020).