An inverse correlation between PD-L1 and miR-34a expression has been observed in various cancers, and miR-34a may enhance the immune recognition in cancer cells by directly targeting PD-L1, resulting in enhanced T-cell responses and an antitumor effect (Wang et al., 2015; Cortez et al., 2016; Anastasiadou et al., 2019). The gene discussed is CD274; the disease is cancer.