For example, miR-34a, delivered via liposomal nanoparticle MRX34 to lung cancer xenograft models grown in immunocompetent mice, increased tumor-infiltrating CD8+ T cells, while it decreased the exhausted CD8+PD1+ T cells and Treg cells (Cortez et al., 2016). The gene discussed is CD8A; the disease is lung carcinoma.