ITGB1 and cancer: To gain insight into the mechanisms underlying the oncogenic roles of ITGB1-DT in LUAD, we focused on the potential regulatory effects of ITGB1-DT on ITGB1 for two reasons: (1) ITGB1-DT is located at the antisense strand of ITGB1; (2) ITGB1 has been reported to exert oncogenic roles in multiple cancers, including LUAD (Wang et al., 2019; Zhang C. et al., 2020).