WNT4 and Mayer-Rokitansky-Kuster-Hauser syndrome: However, the individual role of this gene is not well delimited as WNT4 mutations in MRKH patients not exhibiting hyperandrogenism could not be found (Ravel et al., 2009; Gervasini et al., 2010; Chang et al., 2012) and not all MRKH patients with hyperandrogenism have WNT4 mutations.