Therefore, PD-L1 expression in diverse solid tumors might stratify patients in terms of response to anti-PD-1/PD-L1 immunotherapy and sensitivity to anti-PD-1/anti-PD-L1 mAbs (85), and PD-L1 expression was related to intrinsic and adaptive immune resistance in cancer patients receiving immunotherapy (86). The gene discussed is CD274; the disease is cancer.