CD274 and colorectal carcinoma: The following selection criteria were used: (1) articles published in English; (2) full-text available; (3) studies or trials conducted in human CRCs; (4) relevant mechanistic studies conducted in mice; (5) articles only published as abstract or non-full text publications (case reports, editorials, letters to editors, or meeting abstracts) were excluded; (six) studies were rejected if they lacked sufficient information to study anti-PD-1/PD-L1 therapies in CRC.