CD8A and malaria: Similarly, the baseline frequency of CM in CD8+ T cells was significantly higher in HbAS children than HbAA children (median frequency 7.7% vs. 3.3%, P = 0.020, Supplementary figure 6c, left panel) when only individuals with paired sample available at the time of first malaria episode of the ensuing Pf transmission season were analysed (Supplementary figure 6).