In an ovalbumin-induced asthma model, Vasconcelos et al. [64] demonstrated that the airway smooth muscle hyperreactivity was due to an increase in the formation of superoxide anion and hydrogen peroxide, in addition to a greater expression of iNOS, which culminated in a greater production of peroxynitrite radical and, as a consequence, 8-iso-PGF2α. The gene discussed is NOS2; the disease is asthma.