Ali et al. reported that TERT inhibits the kinase activity of mTOR complex 1 (mTORC1) in multiple cell lines, resulting in the activation of autophagy under both basal and amino acid-deprived conditions [39], whereas, in our present study, the expression level of p-mTOR did not significantly increase after TERT knockdown in U87 glioma cells. This evidence concerns the gene MTOR and central nervous system cancer.