INS and diabetes mellitus: For example, Choi et al. [39] reported that CCA exerted anti-adipogenic activity on 3T3-L1 adipocytes 2 by downregulating C/EBP-α and PPAR-γ; Yang et al. [40] revealed that CCA may help alleviate hyperglycemia in diabetes by promoting glucose uptake by skeletal muscles; and Li et al. [41] concluded that CCA prevent diabetic cognitive deficits most likely by ameliorating disorder of glucose and lipid metabolism, attenuating A-β deposition, and enhancing insulin signaling.