However, in colon cancer, hypoxia-activated HIF-1α inhibits β-catenin-T cell factor-4 (TCF-4) complex formation and transcriptional activity in hypoxia [20], while whether the canonical Wnt and HIF-1α signaling pathway activated by lithium and copper can couple and enhance the osteogenesis-angiogenesis in the BMSCs is still unclear. This evidence concerns the gene HIF1A and malignant colon neoplasm.