Variants in well-known triglyceride-related genes such as BUD13 and SIK3 are known to be associated with triglyceride levels, lipid traits, overall lipid homeostasis, or metabolic syndrome (Kathiresan et al., 2008; Kraja et al., 2011; Keller et al., 2013; Sakamoto et al., 2018). This evidence concerns the gene SIK3 and metabolic syndrome.