CRP and metabolic syndrome: A number of established triglyceride-related variants listed in Supplementary Table 5 have been shown to exhibit pleiotropic effects in European cohorts with elevated C-reactive protein (Ridker et al., 2008; Dehghan et al., 2011; Ligthart et al., 2018), metabolic syndrome traits (Kraja et al., 2011), cholesterol levels (Hoffmann et al., 2018b), cardiovascular risk factors (Middelberg et al., 2011), coronary artery disease (Schunkert et al., 2011; Nelson et al., 2017), among others.