Recent studies have shown that Dicer1 required for transfer RNA-derived fragments (tRF) biogenesis is associated with the development of cancer (Karube et al., 2005; Chiosea et al., 2006, 2007; Flavin et al., 2008; Merritt et al., 2008; Grelier et al., 2009). Here, DICER1 is linked to cancer.