After integrative analysis, we identified B cell (β = 2.956 × 10–4, se = 1.442 × 10–4, P = 0.0228) as cell type associated with HCC in RolyPoly (Figure 3), whereas natural killer cell (NK), monocyte, CD4 + T cell, plasma, macrophage, hepatocyte, regulatory T cell (Treg), endotheliocyte, mesenchymal cell, CD8 + T cell, and dendritic cell (DC) showed no significance (P > 0.05). This evidence concerns the gene CD4 and hepatocellular carcinoma.