For LEPR, a study found that rs1137101 AG and GG carriers with a high fat total intake had 3.0 times higher risk of obesity and 4.1 times higher risk of high cholesterol levels than those with a low intake of total fat (Domínguez-Reyes et al., 2015). This evidence concerns the gene LEPR and obesity due to melanocortin 4 receptor deficiency.