Our data collectively suggests that IL-2 induces IL-13, IL-5, and IFN-γ expression in lupus CD8+ T cells via STAT6-GATA-3 dependent mechanisms in contrast to the Treg differentiation in which IL-2-STAT5 axis plays a more essential role (Figure 1). This evidence concerns the gene GATA3 and systemic lupus erythematosus.