Along this line, there was a positive correlation between the expression of IL-13 and IFN-γ (Figure S3B), resulting in the expansion of IL-13+ IFN-γ+ double-positive CD8+ T cells in SLE (SLE: 20.53 ± 1.48%, HC: 16.15 ± 1.48%, p<0.05, Figures 3A, B) which contracted in association with IL-2 blockade. This evidence concerns the gene CD8A and systemic lupus erythematosus.