Although further studies with large cohorts are needed to demonstrate the accurate role of severity related higher antibody response in COVID-19 patients, our results showed NP-, S-, RBD- specific IgA, IgG, IgM are not associated with SARS-CoV-2 viral load, indicating there is no obvious correlation between antibody response and viral antigen detected in nasopharyngeal swabs. The gene discussed is CD40LG; the disease is COVID-19.