NFKB1 and aneurysm: Aoki, Frò`sen (12) demonstrated that macrophage infiltration driven by MCP-1 and activation of NF-κB involving PGE2-PGEP2 (PGE receptor subtype 2) signaling in the macrophages of arterial wall leads to aneurysm formation, suggesting that inflammation is not only present after aneurysm rupture, but also drives aneurysm formation.