The expression of CD204 in TAMs was associated with a low 5-year disease-free survival (DFS) rate and the aggressiveness of lung adenocarcinoma. In lung adenocarcinoma, CD204+ TAMs located in the tumor stroma area were the preferable marker for prognostic prediction in non-small-cell lung cancer (NSCLC). The gene discussed is MSR1; the disease is neoplasm.