TREM2 and metabolic dysfunction-associated steatohepatitis: Recently, scRNA-seq analysis of the immune cells in murine lipid-associated macrophages (LAMs) (83), NASH-associated macrophages (84), and aortic macrophages (85) indicated that a subset of macrophages expressing triggering receptor expressed on myeloid cells 2 (TREM2), which drives a gene expression program involved in phagocytosis, lipid catabolism, and energy metabolism.