Kuo et al. (48) also identified a subset of inflammatory macrophages expressing heparin-binding EGF-like growth factor in RA joints, which altered synovial fibroblast gene expression profile (e.g., IL-33) via up-regulation of epidermal growth factor receptor (EGFR) response and increased their invasiveness (47, 48). This evidence concerns the gene EGFR and rheumatoid arthritis.