In an experimental xeno-GVHD model, we showed that MT isolated from MSCs and transferred to human PBMCs before their infusion alleviates inflammatory responses leading to significant improvement in the survival and reduction in tissue damage and organ T CD4+, CD8+, and IFN‐γ+ expressing cell infiltration (41). These results represent strong evidence in favor of the hypothesis that the transfer of MSC-derived MT to immune active cells could play a role in the control of immune function mediated by MSCs. This evidence concerns the gene IFNG and graft versus host disease.