Given the relevance of the Th1/Th17 and Treg balance in the outcome of immune mediated diseases and the participation of MSCs in controlling this balance by means of cell-to-cell contact, MT transfer from MSCs to CD4+ T cell subpopulations plays a role in the regulation of T cell function, contributing to the dampening of inflammation that is associated with MSC therapy in graft versus host disease (GVHD) and other immune mediated conditions (39). The gene discussed is CD4; the disease is graft versus host disease.