Data by others indicate that nanoparticle formulations of RA and TGFβ can convert T-cells into Tregs (37), and when administered (nanoparticles or hydrogels) into NOD female mice, they foster an increase in the number of Foxp3+ Tregs inside the PLN and/or the pancreata of diabetes-free mice (58, 59, 62, 63). The gene discussed is TGFB1; the disease is diabetes mellitus.