TNF and rheumatoid arthritis: For treatment of rheumatoid arthritis, several different TNF-alpha inhibitors, such as monoclonal antibody-based therapy (e.g., infliximab, adalimumab, golimumab), or a fusion protein that sequesters TNF-alpha and consists of the extracellular domain of TNF receptor 3 and IgG1-Fc (etanercept) are employed (85).