Autoantibodies in membranous nephropathy are directed against at least two podocyte-specific membrane proteins with extracellularly exposed regions including phospholipase A2 receptor (PLA2R) (34) and thrombospondin type-1 domain-containing 7A (THSD7A) (35) (Figure 2B). This evidence concerns the gene THSD7A and membranous glomerulonephritis.