Other studies have found increased expression of MCP-1, along with other pro-inflammatory cytokines such as IL-1β, IL-6, and TNFα following PAR2 activation in models such as bone marrow-derived macrophages, the murine macrophage cell line RAW264.7, A549 lung cancer cells and human vascular endothelial cells (75–77). This evidence concerns the gene F2RL1 and lung carcinoma.