Variables included systolic and diastolic blood pressure, aspartate aminotransferase (AST), albumin (ALB), Serum creatinine (Scr), blood urea nitrogen (BUN), uric acid (UA), CystatinC (CysC), serum potassium (K), serum sodium (Na), hemoglobin (HB), D-Dimer, NT-proBNP, pulmonary artery systolic pressure (PASP), and comorbidities of renal dysfunction (All P<0.05). The gene discussed is NPPB; the disease is Abnormal renal physiology.