INS and pancreatic insulinoma: Genetic suppression of the key NMD component Smg6, an endoribonuclease which cleaves NMD targeted transcripts at the proximate location of the PTC (Table 2), alleviated cytokine-mediated toxicity associated with increased insulin biosynthesis and glucose–induced insulin secretion in INS-1 cells, a rat insulinoma-derived insulin-producing cell line.