However, after adjustment for age and sex (adjusted model 1) and other metabolic co-morbidities (adjusted model 2), the significant association between elevated serum IL-6 levels and higher risk of severe COVID-19 persisted only in patients with MAFLD (adjusted model 2: OR 1.14 [95% CI 1.05–1.23], p = 0.002). The gene discussed is IL6; the disease is COVID-19.