Among non-MAFLD patients, those with severe COVID-19 were older, had significantly higher levels of WBC, liver enzymes (ALT, AST, GGT, and TBIL), and also had a higher proportion of T2DM, hypertension, and overweight/obesity than those with non-severe COVID-19. The gene discussed is GPT; the disease is obesity due to melanocortin 4 receptor deficiency.