Cox proportional-hazard models adjusted for covariates.Baseline: sex, duration of diabetes, treatment allocation, history of macrovascular or microvascular disease,ever smoker.Time dependent covariates during follow-up: age, HbA1c, body mass index, creatinine, urine albumin to creatinine ratio, systolic blood pressure, diabetes and blood pressure drugs. The gene discussed is ALB; the disease is diabetes mellitus.