Three Cox models for incident CAD constructed, Model 3 fully adjusted adjusting for sex, age, educational attainment, CAD risk factors, insulin, oral hypoglycaemics, total medication count, retinopathy, neuropathy, renal failure, eGFR, LDL < HDL, cancer, dementia, dysrhythmias, hospitalizations, weight loss within a year, HbA1c measurements per year. The gene discussed is INS; the disease is coronary artery disorder.