INS and Graves disease: Incidence of outcome of interest was compared between exposed and unexposed group. Incidence Rate Ratios derived using Poisson regression adjusting for covariates: age, sex, BMI, Townsend deprivation index, smoking, CCI, HbA1c, insulin, bisphosphonates, steroid, hyperthyroidism, Graves disease, renal impariement, antihypertensive medications.