FGF21 and Insulin resistance: This is exciting as adipocytes are a well-known target of FGF21 and intramuscular adipose tissue (IMAT) has emerged as an important player in insulin-resistant associated diseases; high levels of IMAT are associated with insulin resistance and loss of muscle strength (Muoio and Newgard, 2008; Muoio, 2010; Coen and Goodpaster, 2012; Addison et al., 2014).