The present study revealed that BHG and KW treatment protected insulin form increase in PCOS, this is likely attributable to their ability to decrease the level of testosterone, since hyperandrogen has been reported to induce hyperinsulinemia through the regulation of adiponectin, tumor necrosis factor, interleukin-6, leptin, and other factors (Escobar-Morreale, 2018). The gene discussed is TNF; the disease is polycystic ovary syndrome.