Autoinflammatory diseases (IBD) that present with bowel inflammation and intractable diarrhea owing to an inappropriate inflammatory response, with also altered key immune pathways underlying persistent inflammation such as excessive IL-1 signaling, constitutive NF-κB activation, and chronic type I IFN signaling (de Jesus et al., 2015). This evidence concerns the gene NFKB1 and inflammatory bowel disease.