Based on our results, compared with the C allele, the ABCG2 rs2231142 allele A was significantly associated with increased risks of sunitinib-induced thrombocytopenia and HFS in Asians, while the T alleles of ABCB1 rs1128503 and ABCB1 rs2032582 were significantly associated with worse PFS than the other alleles. Here, ABCG2 is linked to Hand-foot syndrome.