ABCG2 and Hand-foot syndrome: Although other previous studies have reported that the ABCG2 rs2231142 polymorphism is not significantly associated with toxicity-related dose reduction (Garcia-Donas et al., 2011; Kato et al., 2017; Zhang et al., 2018) or time to dose reduction in mRCC patients (Numakura et al., 2017), further studies should verify whether dose adjustment based on early onset thrombocytopenia and HFS in Asians prolongs sunitinib treatment.