ABCG2 and Hand-foot syndrome: Garcia-Donas et al. reported that the A allele of ABCG2 rs2231142 seemed to confer protection against HFS in Caucasians (Garcia-Donas et al., 2011), while in the other four studies carried out in Asians, an increased risk of development of HFS was found (Kim et al., 2013; Low et al., 2016; Numakura et al., 2017; Zhang et al., 2018).