ABCB1 and hypertensive disorder: Patients carrying the variant genotypes of rs1128503 and rs2032582 in ABCB1 showed an increased clearance of sunitinib and its active metabolite SU12662, consequently leading to lower exposure to sunitinib, reduced hypertension, and decreases in PFS and OS (Garcia-Donas et al., 2011; Beuselinck et al., 2014; Diekstra et al., 2014; Teo et al., 2015).