LRIG2 and central nervous system cancer: In glioma cells, overexpression of miR-503 reduced both LRIG2 (Leucine-rich repeats and immunoglobulin-like domains protein 2) and VEGFA expression levels (Sun et al., 2019), and suppressed angiogenesis in cocultured human cerebral microvascular endothelial cell line D3 (HCMEC/D3), while miR-503 inhibitor promoted angiogenesis in cocultured HCMEC/D3.