LRIG2 was proven as miR-503 target by luciferase assay, knockdown of LRIG2 reduced VEGFA expression level along with the condition of miR-503 inhibitor, therefore, miR-503 regulated angiogenesis in glioma by reducing LRIG2 expression followed by downregulation of VEGFA expression (Sun S. et al., 2019). Here, VEGFA is linked to central nervous system cancer.