In pulmonary arterial hypertension (Jongmin et al., 2012), both hsa-miR-424 and hsa-miR-503 were decreased in pulmonary artery endothelial cells derived from patients with pulmonary arterial hypertension, and overexpression of both miRs in animal models of pulmonary hypertension can alleviate pulmonary hypertension by downregulation of FGF2 and FGF receptor (FGFR1) (Jongmin et al., 2012). This evidence concerns the gene FGF2 and pulmonary arterial hypertension.