LRIG2 belongs to the leucine-rich repeats and immunoglobulin-like domains family and regulates epidermal growth factor receptor (EGFR) signaling pathway (Simion et al., 2014), and downregulation of LRIG2 suppressed angiogenesis in glioma (Yang et al., 2017). The gene discussed is EGFR; the disease is central nervous system cancer.