Another study investigated the effects of dual RAS blockade with ACEI and ARB on ACE2 expression, hypertension and renal proximal tubular cell (RPTC) apoptosis in type 1 diabetic Akita angiotensinogen (Agt)-transgenic (Tg) mice that specifically overexpress Agt in RPTCs (Lo et al., 2012). Here, ACE2 is linked to hypertensive disorder.