In models of various pathological conditions (hypertension (Igase et al., 2005; Agata et al., 2006; Jessup et al., 2006; Whaley-Connell et al., 2006; Takeda et al., 2007; Zhong et al., 2011; Yang et al., 2014), myocarditis (Sukumaran et al., 2011; Sukumaran et al., 2012a), diabetes (Lo et al., 2012; Graus-Nunes et al., 2019) and smoking (Han et al., 2010), details are shown in Table 1), ACEIs and/or ARBs led to normalization of decreased ACE2 expression or elevated it above the control levels. This evidence concerns the gene ACE2 and hypertensive disorder.